Due to an injury, Diego Simeone's team was forced to make an early substitution, as midfielder Koke was replaced by Pablo Barrios after only six minutes.
Varo Morata pounced deep in first-half extra time after the visitors only partially cleared a corner, giving the Rojiblancos their first lead of the game.
Soon after the hour mark, Samu Omorodin connected with substitute Gonzalo Villars, who then threaded a ball for a shot into Jan Oblak’s nett.
Memphis Depay, though, restored the hosts' advantage only five minutes later with a powerful long-range attempt.
After Marcos Llorente scored a third goal with essentially the game's final kick, the colchoneros were on their way to the top.
According to goal difference, Atleti are ahead of Osasuna, as well as city rivals Real Madrid and Rayo Vallecano.">